Identifikasi Kalsium dan Magnesium dalam Obat Menggunakan LIPS (Laser-Induced Plasma Spectroscopy)

Heri Sugito; Ali Khumaeni; Wahyu Setia Budi; Asep Yoyo Wardaya

doi:10.31596/cjp.v4i1.78

Identifikasi Kalsium dan Magnesium dalam Obat Menggunakan LIPS (Laser-Induced Plasma Spectroscopy)

DOI: https://doi.org/10.31596/cjp.v4i1.78

Heri Sugito^(1*), Ali Khumaeni⁽²⁾, Wahyu Setia Budi⁽³⁾, Asep Yoyo Wardaya⁽⁴⁾

(1) Department of Physics Diponegoro University
(2) Department of Physics Diponegoro University
(3) Department of Physics Diponegoro University
(4) Department of Physics Diponegoro University
(*) Corresponding Author

Abstract

Identifikasi kandungan zat makro pada obat-obatan kimia sangat diperlukan untuk tujuan perlindungan kesehatan masyarakat. Dalam penelitian ini, identifikasi magnesium (Mg) dalam produk farmasi dilakukan menggunakan LIPS (Laser-Induced Plasma Spectroscopy). Laser yang digunakan pada penelitian adalah laser Nd: YAG dan laser CO₂. sampel yang digunakan adalah tablet suplemen. Sinar laser diarahkan dan difokuskan oleh lensa cembung pada sampel. Berkas plasma diinduksikan pada permukaan sampel. Spectrum emisi yang tajam dan berintensitas tinggi yang terdeteksi menggunakan laser Nd:YAG menunjukkan adanya kandungan Kalsium (Ca) dan Magnesium (Mg) pada sampel. Hasil yang diperoleh kemudian dibandingan dengan pengujian sampel menggunakan laser CO₂. Diperoleh hasil intensitas spectrum Mg jauh lebih tinggi menggunakan laser CO₂.

Keywords

LIPS; Nd; YAG; Laser CO2; Magnesium; Kalsium

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References

Cremers D. A., dan Radziemski L. J. (2006). Handbook of Laser-Induced Breakdown Spectroscopy (John Wiley and Sons Ltd, Chichester).

Ho, C.-Y. and S.-J. Jiang. (2002). Determination of Cr, Zn, Cd and Pb in milk powder by slurry sampling electrothermal vaporization inductively coupled plasma mass spectrometry. Journal of Analytical Atomic Spectrometry 17(7): 688-692.

Khumaeni, A., et al. (2010). A novel double-pulse laser plasma spectroscopic technique for H analysis in metal samples utilizing transversely excited atmospheric-pressure CO2 laser-induced metastable He atoms. Optical Review 17(3): 285-289.

Ali Khumaeni, Zener Sukra Lie, Hideaki Niki, Yong Inn Lee, Kazuyoshi Kurihara, Motoomi Wakasugi, Touru Takahashi, and Kiichiro Kagawa, (2012). Comparative study of Nd:YAG laser-induced breakdown spectroscopy and transversely excited atmospheric CO2 laser-induced gas plasma spectroscopy on chromated copper arsenate preservative-treated wood. Appl. Opt. 51, B121-B129.

Khumaeni, A., et al. (2012). Emission Characteristics of Ca and Mg Atoms in Gas Plasma Induced by the Bombardment of Transversely Excited Atmospheric CO$_{2}$ Laser at 1 atm. Japanese Journal of Applied Physics 51: 082403.

Miziolek W, Palleschi V, Schechter, I.(2006). Laser-induced Breakdown Spectroscopy (LIBS), Fundamentals and Applications (Cambridge University Press, New York).

Porta, R., et al. (2016). Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products.Organic Process Research & Development 20(1): 2-25.

Tame A, and Hoobin D. (1999). ICP-AES Instrument at Work Varian.

St-Onge L., Kwong E., Sabsabi M., Vadas E. B. (2002). Quantitative analysis of pharmaceutical products by laser-induced breakdown spectroscopy. Spectrochim. Acta B Volume 57, Issue 7, p. 1131-1140.

DOI: https://doi.org/10.31596/cjp.v4i1.78