RASIONALITAS PENGGUNAAN ANTIMIKROBA RESERVE DI RUANG INTENSIVE CARE UNIT RUMAH SAKIT DI BALI PASCA PROGRAM PENGENDALIAN RESISTENSI ANTIMIKROBA

Ida Ayu Made Erma Ariningsih; TB. Titien Siwi Hartayu

doi:10.31596/cjp.v9i2.329

RASIONALITAS PENGGUNAAN ANTIMIKROBA RESERVE DI RUANG INTENSIVE CARE UNIT RUMAH SAKIT DI BALI PASCA PROGRAM PENGENDALIAN RESISTENSI ANTIMIKROBA

DOI: https://doi.org/10.31596/cjp.v9i2.329

Ida Ayu Made Erma Ariningsih^(1*), TB. Titien Siwi Hartayu⁽²⁾

(1) Magister Farmasi Sanata Dharma University
(2) Sanata Dharma University
(*) Corresponding Author

Abstract

Antimicrobials are used to treat patient with infectious diseases. Inappropriate use oof antimicrobials can trigger bacteria that are resistant to antimicrobials. Reserve group of antimicrobials are antimicrobials which is reserved and are used for the treatment of patients with MDRO. In an effort to increase the rational use of antimicrobials, the government formed KPRA which us tasked with controlling the use of antimicrobials in hospitals, One of the private hospital in Bali has also formed KPRA since 2018. The use of antimicrobials in the ICU is quite high, but there is no data regarding antimicrobial control rate in the ICU, so it is important to analyze the use of antimicrobials in the ICU after KPRA. This study aims to determine the rationality of using reserve group antimicrobials in the ICU. This research is a descriptive analytical study, quasi-experimental design. Data was taken retrospectively from June 2017-May 2021. The study population was all hospital inpatient during the study period. The research subjects were all patients in the ICU. Data source from patient medical records and HIS. The sample size is the total that meets the criteria. Inclusion criteria were all patient in the ICU with reserve antimicrobials group in the period June 20017-May 2029 (pre-PPRA) and June 2019-May 2021 (post PPRA). Exclusion criteria were all patients in the ICU but the data was incomplete. Data analysis uses DDD calculations and the Gyssen method. The result showed that the DDD rate did not change significantly. The most widely used antimicrobials are Ceftriaxone 1G, Levofloxacin 500mg, Levofloxacin 750mg, and Meropenem 1G. The number of vials used for antimicrobials in the ICU decreased by 75.46%. Rational use of reserve group antimicrobials after PPRA implementation increased by 42.85%. The rationality of using reserve group antimicrobials in the ICU after PPRA increase.

Keywords

PPRA; antimicrobial; Gyssen

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References

Farida, Herawati, Hapsari, M. and Notoatmodjo, Harsoyo, H. (2008) ‘Penggunaan Antibiotik Secara Bijak untuk Mengurangi Resistensi Antibiotik, Studi Intervensi di Bagian Kesehatan Anak RS Dr. Kariadi’, 10(1), pp. 34–41.

Gilchrist, M. et al. (2017) ‘Antibiotic stewardship in the intensive care unit’, Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill, pp. 265–275. doi: 10.1007/978-981-10-5336-8_13.

Kementerian Kesehatan RI (2015) ‘Peraturan Menteri Kesehatan nomor 8 tahun 2015’, Pedoman Pencegaha dan Pengendalian Resistensi Antimikroba, (334), pp. 1–31.

Kristi, G. (2021) ‘Penemuan Kasus Penyakit Menular di Indonesia Selama 2020-2021: Kajian Literatur’, Fakultas Kesehatan Masyarakat Universitas Indonesia, (December), pp. 1–9.

Kuniano, D. (2015) ‘Menjaga Kesehatan di Usia Lanjut’, Jurnal Olahraga Prestasi, 11(2), pp. 19–30.

Theuretzbacher, U. (2013) ‘Global antibacterial resistance: The never-ending story’, Journal of Global Antimicrobial Resistance, 1(2), pp. 63–69. doi: 10.1016/j.jgar.2013.03.010

DOI: https://doi.org/10.31596/cjp.v9i2.329