Aplikasi Konsorsium Tanaman Herbal untuk Mengatasi Jerawat Akibat Autoimun Suatu Upaya Pengembangan Traditional Biomedicine

Yosef Purwoko; Hermin Pancasakti Kusumaningrum; Lilis Sugiarti; Hererapratita Aysha Hapsari

doi:10.31596/cjp.v4i1.83

Aplikasi Konsorsium Tanaman Herbal untuk Mengatasi Jerawat Akibat Autoimun Suatu Upaya Pengembangan Traditional Biomedicine

DOI: https://doi.org/10.31596/cjp.v4i1.83

Yosef Purwoko⁽¹⁾, Hermin Pancasakti Kusumaningrum^(2*), Lilis Sugiarti⁽³⁾, Hererapratita Aysha Hapsari⁽⁴⁾

(1) Laboratorium Fisiologi, Fakultas Kedokteran, Universitas Diponegoro
(2) Program Studi Bioteknologi, Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro
(3) STIKES Cendekia Utama Kudus
(4) Laboratorium Fisiologi, Fakultas Kedokteran, Universitas Diponegoro
(*) Corresponding Author

Abstract

Jerawat merupakan salah satu penyakit kulit autoinflamasi yang terkait dengan autoimmun yang biasa dijumpai para remaja di Indonesia. Permasalahannya, ternyata penyakit ini mempunyai prevalensi seumur hidup sebesar 85% dan menimbulkan dampak mekanisme inflamasi kompleks yang melibatkan imunitas bawaan. Bahkan bagi wanita yang berusia di atas usia 25 tahun, pengobatan jerawat menggunakan obat kimiawi mempunyai tingkat kegagalan yang tinggi. Kebutuhan akan pengembangan obat tradisional menjadi salah satu solusi untuk mengatasi permasalahan tersebut, khususnya terkait dengan keamanan dan kemudahan dalam penggunaannya serta mempunyai efek samping yang lebih kecil. Tanaman herbal di Indonesia telah menarik banyak perhatian karena penggunaannya secara tradisional dalam kehidupan sehari-hari yang telah banyak memecahkan permasalahan terkait dengan beberapa penyakit kulit yang disebabkan oleh autoimun. Tujuan penelitian adalah menentukan aktivitas konsorsium tanaman herbal dalam menghambat mikroorganisma penyebab jerawat. Metode penelitian dilakukan dengan mengisolasi mikroorganisme penyebab jerawat dan melakukan uji penghambatan pertumbuhan mikroorganisme yang berasal dari pasien penderita jerawat dibandingkan dengan kontrol menggunakan rebusan konsorsium tanaman herbal dan menganalisis potensi aktivitas obat jerawat dari setiap tanaman menggunakan analisis PASS. Hasil penelitian memperlihatkan 21 jenis tanaman herbal mempunyai aktivitas dalam mengatasi penyakit kulit yang terkait dengan autoimun dan mikroorganisme. Uji aktivitas antimikroorganisme menunjukkan diameter zona hambatan pertumbuhan sebesar 2 - 5 mm sesuai dengan semakin banyaknya larutan. Hasil analisis PASS memperlihatkan bahwa tanaman sambiloto (Andrographis paniculata) memperlihatkan potensi tertinggi dalam mengobati jerawat dengan kemampuan sebesar 86%. Meskipun demikian, hasil penelitian memperlihatkan potensi tanaman herbal sebagai obat jerawat akibat autoimun akan mencapai hasil yang lebih optimal bila digunakan bersama-sama.

Keywords

herbal; jerawat; tanaman; tradisional

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References

Ali, N.A.M., Ismail, N., Taib, M.N. 2012. Analysis of Agarwood Oil (Aquilaria Malaccensis) Based on GC-MS Data. IEEE 8th International Colloquium on Signal Processing and its Applications 470-473

Balouiri M, Sadiki M, Ibnsouda SK. 2016. Review Paper Methods for in vitro evaluating antimicrobial activity: A review$, Journal of Pharmaceutical Analysis 6: 71–79.

Baker BS. 2006. The role of microorganisms in atopic dermatitis. Review. Clinical and Experimental Immunology, 144: 1–9.

Bakkali F, Averbeck S, Averbeck D, Idaomar M. 2010. Biological effects of essential oils . A review. Institut Curie-Section de Recherche, UMR2027 CNRS/IC, LCR V28 CEA, Baˆ t. 110, Centre Univ, 91405 Orsay cedex, France : 446-476

Balouiri M, Sadiki M, Ibnsouda SK, 2016. Review Paper Methods for in vitro evaluating antimicrobial activity: A review$, Journal of Pharmaceutical Analysis 6: 71–79.

Bhate, K.,Williams, H.C.2013. Epidemiology of acne vulgaris. British Journal of Dermatology 168(3):474–85.

Blasiak, R.C., Stamey, C.R., Burkhart, C.N., Lugo-Somolinos, A., Morrell, D.S. 2013. High-dose isotretinointreatment and the rate of retrial, relapse, and adverse effects in patients with acne vulgaris. JAMA Dermatology 149(12):1392–8.

Bure CM, Sellier NM. 2004. Analysis of the essential oil of Indonesian Patchouli (Pogostemon cablin Benth) using GC/MS (EI/CI). Journal of Essential Oil Research 16: 17–19.

Chao, SG. Young C. Oberg and Karen. 2008. Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by essential oils. Flavour and Fragrance Journal. 23: 444–449.

Chakrapani P, Venkatesh K, Chandra Sekhar Singh B, Arun Jyothi B, Prem Kumar, Amareshwar iP, Roja Rani A. 2013. Review Phytochemical, Pharmacological importance of Patchouli (Pogostemon cablin (Blanco) Benth) an aromatic medicinal plant. International Journal of Pharmaceutical Sciences Review and Research. 21(2): 7-15.

Corine MB, Sellier NM. 2004, Analysis of the essential oil of Indonesian patchouli (Pogostemon cablin Benth.) using GC/MS (EI/CI). Journal of Essential Oil Research 3: 16-17.

Das K, Gupta S. Vijayabhaskar, Manjunath U.M. 2011. Antimicrobial Potential of Patchouli Oil Cultivated Under Acidic Soil Zone Of South India. Indian Journal of Novel Drug delivery 3(2): 104-111

Djilani A, Dicko A. 2012. The therapeutic benefits of essential oils. www.intechopen.com : 155-178

Geetha, D.H., Jayashree, I., Rajeswari, M. 2019. GC-MS Analysis of Bioactive Compounds of Ethanolic Seed Extract of Elaeocarpus serratus. International Journal of Pharmaceutical Sciences and Drug Research 11(1): 31-34

Goulden, V., Clark, S.M., McGeown, C., Cunliffe, W.J.1997. Treatment of acne with intermittent isotretinoin. British Journal of Dermatology 137(1):106–8.

Hanwar, D., Dewi, M.S., Suhendi, A., Trisharyanti, I.D.K. 2015. Analysis of secondary metabolites profile of lempuyang gajah (Zingiber zerumbet smith) ethanol extract using gas chromatography mass spectroscopy with derivatization 7(2) : 1-8

Hidayat, N., Dewi, I.A., Hardani, D.A. Ekstraksi minyak melati Ekstraksi Minyak Melati (Jasminum sambac) (Kajian Jenis Pelarut dan Lama Ekstraksi) Jurnal Industria 4(2): 82 – 88.

Hussein, H.M., HadiHameed, I.2016. Antibacterial Effect of Ginger (Zingiber officinale) Roscoe and Bioactive Chemical Analysis using Gas Chromatography Mass Spectrum Orient. J. Chem., Vol. 32(2), 817-837

Imanta, E., Hidajati, N. 2017. Uji biolarvasida nyamuk aedes aegypty dari hasil isolasi ekstrak metanol tanaman sambiloto (Andrographis paniculata NESS). UNESA Journal of Chemistry 6(1)

Jain A, Jain S, Rawat S. Emerging fungal infections among children: A review on its clinical manifestations, diagnosis, and prevention. Journal of Pharmacy and Bioallied Sciences 2 (4): 314-320.

Jamal, Y., Irawati, P., Fathoni, A., Agusta, A. 2013. Chemical constituents and antibacterial effect of essential oil of Javaneese pepper leaves (piper retrofractum vahl.). Media Litbangkes 23(2) : 65-72

Jantamas S., N. Matan, N. Matan and T. Aewsiri. 2016. Improvement of antifungal activity of citronella oil against Aspergillus flavus on rubberwood (Hevea brasiliensis) using heat curing. Journal of Tropical Forest Science 28(1): 39–47

Judarwanto. W. 2009. Children Allergy Center Picky Eaters Clinic Jakarta (Klinik Kesulitan Makan) RS. Bunda Jakarta. Jl Rawasari Selatan 50 Jakarta Pusat. Jl Taman Bendungan Asahan 5 Bendungan Hilir Jakarta Pusat telp : (021) 70081995 – 4264126 – 31922005, email : wido25@hotmail.com , http://alergianak.bravehost.com

Kailavani, C.S., Sathish, S.S., Janakiraman, N., Johnson, M. 2012. GC-MS Studies on Andrographis panuculata (Burn.f.) Wall. Ex Nees – A medicinally important plant. Int.J.Med.Arom.Plants. 2(1) 69-74

Kamangar, F., Shinkai, K.2012. Acne in the adult female patient: a practical approach. International Journal of Dermatology 51(10):1162–74.

Kasuan, N., Muhammad, Z., Yusoff, Z., Rahiman, M.D.F., Taib, M.N., Haiyee, Z.A. 2013. Extraction of citrus hystrix d.c. (kaffir lime) essential oil using automated steam distillation process: analysis of volatile compounds. Malaysian Journal of Analytical Sciences, 17(3): 359 – 369

Kusumaningrum, H.P., Kusdiyantini, E., Pujiyanto, S. 2015. Kualitas Simplisia Tanaman Biofarmaka Curcuma domestica setelah Proses Pemanasan pada Suhu dan Waktu Bervariasi. Jurnal Bioma 17(1): 27-33

Kusumaningrum, H.P., Zainuri, M., Purbajanti, E.D., Endrawati, H. 2019. Characterization of Citronella Grass Essential oil of Cymbopogon winterianus from Batang Region, Indonesia. International Conference ISNPINSA 1-11

Kaur, R., Kaur, H. 2010. The Antimicrobial activity of essential oil and plant extracts of Woodfordia fruticosa. Arch. Appl. Sci. Res., 2 (1)302-309

Murthy, A.S., and Leslie, K. 2016. Autoinflammatory Skin Disease:A Review of Concepts and Applications to General Dermatology. Dermatology 232:534–540. DOI: 10.1159/000449526

Mateblowski, M. 1991. Curcuma xanthorrhiza Roxb, penerbit PMI Verlag, ISBN 3-89119-173-1, ISBN 978-3-89119-173-6, halaman 36

Nugraha, A.S., Wangchuk, T., Willis, A.C., Haritakun, R., Sujadmiko, H., Keller, P.A.2019. Phytochemical and Pharmacological Studies on Four Indonesian Epiphytic Medicinal Plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii. Natural Product Communications 1-6

Orchard A, van Vuuren S. 2017. Article Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases. Hindawi Evidence-Based Complementary and Alternative Medicine Volume Article ID 4517971 : 1-92

Simic A., A. Rancic, M.D. Sokovic, M. Ristic, S. Grujic-Jovanovic, J. Vukojevic, and P.D. Marin. 2008. Essential Oil Composition of Cymbopogon winterianus and Carum carvi and Their Antimicrobial Activities. Pharmaceutical Biology 46(6):437–441

Swamy, M.K and U.R. Sinniah. 2015. A Comprehensive Review on the Phytochemical Constituents and Pharmacological Activities of Pogostemon cablin Benth.: An Aromatic Medicinal Plant of Industrial Importance. Review. ISSN 1420-3049. www.mdpi.com/journal/molecules..doi:10.3390/molecules 20058521. Molecules (20) : 8521-8547

Tyani, E. S., Utomo, W. dan Hasneli, Y. (2015). Efektivitas relaksasi otot progresif terhadap tekanan darah pada penderita hipertensi esensial, JOM, vol. 2 no. 2,hal. 1068-1075.

Tan, A.U., Schlosser, B.J., and Paller A.S. 2018. A review of diagnosis and treatment of acne in adult female patients. Review. International Journal of Women's Dermatology vol. 4., hal. 56–71.

Rademaker, M. 2016. Making sense of the effects of the cumulative dose of isotretinoin in acne vulgaris. International Journal of Dermatology 55(5):518–23.

Timotius, K.H., Sari, I. N., Santoso, A.W. 2015. Major Bioactive Compounds of Pilis Plant Materials: A GC-MS Analysis. Pharmacognosy Communications 5(3)

Parwata, I.M.O.A., Rita, W.S., Yoga, R. 2009. Isolasi dan uji antiradikal bebas minyak atsiri pada daun sirih (Piper betle Linn) secara spektroskopi ultra violet-tampak. Jurnal Kimia 3 (1): 7-13

Papitha, M., Lokesh, R., Kaviyarasi, R., Selvaraj, C. 2016.Phytochemical Screening, FT-IR and Gas Chromatography Mass Spectrometry Analysis of Tinospora cordifolia (Thunb.) International Journal of Pharmacognosy and Phytochemical Research 8(12); 2020-2024

Priya, V., Jananie, R. K., Vijayalakshmi K. 2011. GC/MS determination of bioactive components of Trigonella foenum grecum. J. Chem. Pharm. Res., 3(5):35-40

Rina, O. 2013. Identifikasi Senyawa Aktif dalam Ekstrak Etanol Kayu Secang (Caesalpinia sappan. L.), Prosiding Semirata FMIPA Universitas Lampung, 2013 1-4

Sukandar, D., Hermanto, S., Lestari, E. 2008. Uji Toksisitas Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Dengan Metode Brine Shrimp Lethality Test (BSLT). Jurnal Kimia Valensi 1(2) 63-70

Suphroma, N., Sonyota, W., Insumronga, K., Sawangsupa, P., Sutamuanga, P., Ingkaninan, K. 2017. GC-MS analysis and in vitro anti-androgenic activity of Kaempferia rotunda Linn extract. Naresuan University Journal: Science and Technology (25)4: 34-43

Thambi, M., Cherian, T. 2015. Phytochemical investigation of the bark of Strychnosnux-vomica and its antimicrobial properties. The Pharma Innovation Journal 4(5): 70-72

Upadhyay, R.K. 2015. GC-MS Analysis and in Vitro Antimicrobial Susceptibility of Foeniculum vulgare Seed Essential Oil. American Journal of Plant Sciences, 6, 1058-1068

Widyowati, R., Agil, M. 2018. Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu. Chem. Pharm. Bull. 66, 506–518

Yang X, Zhang X, Yang S and Liu W. 2013. Evaluation of the Antibacterial Activity of Patchouli Oil. Iranian Journal of Pharmaceutical Research 12 (3): 307-316

Wartini, N.M., Ina, P.T., Ganda Putra,G.P. 2010. Perbedaan kandungan senyawa volatil daun salam (Eugenia polyantha wight) pada beberapa proses curing. Agritech 30(4)

Wu, H., J. Li., Y. Jia., Z. Xiao., P. Li., Y. Xie., A. Zhang., R. Liu., Z. Ren., M. Zao., C. Zeng and C. Li. 2019. Essential Oil Extracted from Cymbopogon citronella Leaves by Supercritical Carbon Dioxide: Antioxidant and Antimicrobial Activities. Journal of Analytical Methods in Chemistry 2019 : 1-10

DOI: https://doi.org/10.31596/cjp.v4i1.83