Potensi Herba Bandotan (Ageratum conyzoides L.) sebagai Agen Antikanker Payudara

DOI: https://doi.org/10.31596/cjp.v6i1.153

Lintang Adelya(1), Pisga Chrisita Dewi(2), Zerlinda Clara Auw(3), Radhita Tyastu Puteri Winengku(4), Mase Mase(5), Dewi Setyaningsih(6), Florentinus Dika Octa Riswanto(7*)

(1) Fakultas Farmasi, Universitas Sanata Dharma
(2) Fakultas Farmasi, Universitas Sanata Dharma
(3) Fakultas Farmasi, Universitas Sanata Dharma
(4) Fakultas Farmasi, Universitas Sanata Dharma
(5) Fakultas Farmasi, Universitas Sanata Dharma
(6) Fakultas Farmasi, Universitas Sanata Dharma
(7) Fakultas Farmasi, Universitas Sanata Dharma
(*) Corresponding Author

Abstract


Kanker payudara termasuk dalam kasus yang paling banyak terjadi di Indonesia. Berbagai upaya penanganan kanker telah dilakukan, namun dinilai belum memuaskan mengingat efek samping yang cukup serius. Keragaman hayati mendorong pengujian bahan-bahan alam yang berpotensi sebagai agen antikanker payudara. Bandotan (Ageratum conyzoides L.) secara empiris diketahui memiliki berbagai efek farmakologis termasuk sebagai agen antikanker. Penulisan review artikel ini menggunakan metode studi pustaka. Beberapa hasil penelitian menunjukkan adanya kandungan senyawa fitokimia pada herba bandotan seperti flavonoid, chromene, terpenoid, alkaloid, minyak atsiri, kumarin, sterol, glikosida, tanin dan saponin yang terbukti memiliki aktivitas antikanker. Oleh karena itu, herba bandotan (Ageratum conyzoides L.) diyakini memiliki potensi besar sebagai agen antikanker payudara. Namun masih perlu dilakukan pengujian lebih lanjut secara in vivo maupun in vitro mengenai efektivitas dan keamanan herba bandotan sebagai agen antikanker payudara.


Keywords


kanker payudara; herba bandotan; antikanker; fitokonstituen

Full Text:

PDF

Article Metrics

Abstract viewed : 271 times | PDF files downloaded : 347 times

References


Aboudoulatif, D., Selva, D., Gunasekaren, V., Jagadeesan, S. G., Kwashie, E. G., Muthiah, R. and Edmond, C. E. (2015). In vitro and in vivo genotoxicity assessment of total alkaloids of Ageratum conyzoides L. Leaves (Asteraceae) by alkaline comet assay. International Journal of Pharmaceutical Sciences and Research, vol. 6, no. 7, p. 2320-5148.

Adebayo, A. H., Ji, C. J., Zhang, Y. M., He, W. J., Zeng, G. Z., Han, H. J., Xu, J. J., Akindahunsi, A. A. and Tan, N. H. (2011). A New Chromene Isolated from Ageratum conyzoides. Natural Product Communication, vol. 6, no. 9, p. 1263-1265.

Adebayo, A. H., Tan, N. H., Akindahunsi, A. A., Zeng, G. Z. and Zhang, Y. M. (2010). Anticancer and antiradical scavenging activity of Ageratum conyzoides L.(Asteraceae). Pharmacognosy magazine, vol. 6, no. 21, p. 62.

Amadi, B. A., Duru, M. K. C. and Agomuo, E. N. (2012). Chemical profiles of leaf, stem, root and flower of Ageratum conyzoides1. Pelagia Research Library, vol. 2, no. 4, p. 428-432.

Antai, A. B., Eyong, E. U., Eteng, M. U., Itam, E. H., Eko, M. E., dan Ita, S. O. (2009). Serum protein and enzyme levels in rats following administration of ethanolic leaf extract of Ageratum conyzoides (goat weed). Nigerian Journal of Physiological Sciences, vol. 24, no. 2, pp. 117–120.

Bae, H., Song, G. and Lim, W. (2020). Stigmasterol causes ovarian cancer cell apoptosis by inducing endoplasmic reticulum and mitochondrial dysfunction. Pharmaceutics, vol. 12, no. 6, p. 488.

Bakar, M. F. A,., Saifudin, A., Cao, P. and Esa, N. M. (2021). Herbal Medicine for Prevention and Therapy in Breast Cancer. Hindawi, vol. 2021, no. 2021, p. 1-4.

Bayala, B., Bassole, I. H. N., Gnoula, C., Nebbie, R., Yonli, A., Morei, L., Figueredo, G., Nikiema, J. B., Lobaccaro, J. M. A. and Simpore, J. (2014). Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso. PLoS one, no. 9, vol. 3, p. 1-11.

Chahal, R., Nanda, A., Akkol, E. K., Sobarzo-Sánchez, E., Arya, A., Kaushik, D. and Mittal, V. (2021). Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens. Molecules, vol. 26, no. 10, p. 2933.

Chanda, S. and Nagani, K. (2013). In vitro and in vivo Methods for Anticancer Activity Evaluation and Some Indian Medicinal Plants Possessing Anticancer Properties: A Overview. Journal of Pharmacognosy and Phytochemistry, vol. 2, no. 2, p. 140-152.

Chen, W. L., Bai, H. H., Liu, L. W., Chen, H, Y., Shi, Q., Chang, L. S., Gou, X. J. and Qian, J. (2021). Fuzheng Yiliu Formula Regulates Tumor Invasion and Metastasis through Inhibition of WAVE3 Expression. Hindawi, vol. 2021, no. 2021, p. 1-14.

Cyprian, F. S., Akhtar, S., Gatalica, Z. and Vranic, S. (2019). Targeted Immunotherapy With A Checkpoint Inhibitor in Combination with Chemotherapy: A New Clinical Paradigm In The Treatment of Triple-negative Breast Cancer. Bosnian Journal of Basic Medical Sciences, vol. 19, no. 3, p. 227.

Dahham, S. S., Tabana, Y. M., Iqbal, M. A., Ahamed, M. B. K., Ezzat, M. O., Majid, A. S. A. and Majid, A. M. S. A. (2015). The anticancer, antioxidant and antimicrobial properties of the sesquiterpene ?-caryophyllene from the essential oil of Aquilaria crassna. Molecules, vol. 20, no. 7, p. 11808-11829.

Ekor, M. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Font Pharmacol, vol. 4, no. 177, p. 1-10.

Fuslin., Fitrawan, L. O., Pascayantri, A. dan Adjeng, A. N. T. (2020). Sosialisasi dan Edukasi Pemanfaatan Tanaman Berkhasiat Obat dalam Menghadapi Masa Pandemi COVID-19 di Kota Kendari. Jurnal Mandala, vol. 1, no. 2, p. 62-69.

Febriansah, R. dan Komalasari, T. (2019). Co-Chemotherapeutic Effect of Ageratum conyzoides L. Chloroform Fraction and 5-Fluorouracil on Hela Cell Line. Pharmacognosy Journal, vol. 11, no. 5, p. 913-918. Doi: 10.5530/pj.2019.11.146.

Fidyt, K., Fiedorowicz, A., Strz?da?a, L. and Szumny, A. (2016). ??caryophyllene and ??caryophyllene oxide—natural compounds of anticancer and analgesic properties. Cancer medicine, vol. 5, no. 10, p. 3007-3017.

GLOBOCAN. 2020. The Global Cancer Observatory. All Rights Reserved.

Hao, J. J., Gong, T. and Zhang, M. (2013). Characterization of gene rearrangement resulted from genomic structural aberrations in human esophageal squamous cell carcinoma KYSE150 cells. Gene, vol. 513, no. 1, p. 196-201.

Hariono, M., Rollando, R., Karamoy, J., Hariyono, P., Atmono, M., Djohan, M. and Wahab, H. (2020). Bioguided fractionation of local plants against matrix metalloproteinase9 and its cytotoxicity against breast cancer cell models: In silico and in vitro study. Molecules, vol. 25, no. 20, p. 4691.

Hilaliyah, R. (2021). Pemanfaatan Tumbuhan Liar Bandotan (Ageratum conyzoides L.) sebagai Obat Tradisional dan Aktivitas Farmakologinya. Bioscientiae, vol. 18, no. 28-36 , p. 28–36.

Hossain, H., Karmakar, U. K., Biswas, S. K., Shahid-Ud-Daula, A. F. M., Jahan, I. A., Adnan, T. and Chowdhury, A. (2013). Antinociceptive and antioxidant potential of the crude ethanol extract of the leaves of Ageratum conyzoides grown in Bangladesh. Pharmaceutical Biology, vol. 51, no. 7, p. 893-898.

Irmawan, M., Mandey, F. and Dali, S. (2018). Isolation, Identification, Characterization, And Toxicity Essay Of Non-polar Secondary Metabolite Fraction From Ageratum conyzoides L. Indo. J. Chem. Res. vol. 6, no. 1, p. 513–517.

Isah, T. (2016). Anticancer Alkaloids from Trees: Development into Drugs. Pharmacognosy reviews. vol. 10, no. 20, p. 90–99.

Ji, Y., Li, S., Zhang, X., Li, Q., Lu, Q., Chen, W., Liu, Y., Sheng, J., Liang, H., Jiang, K., Li, M., Sha, S.,Wu, H., Huang, Y. and Xue, X. (2021). The Efficacy of Moxibustion for Breast Cancer Patient with Chemotherapy-Induced Myelosuppression during Adjuvant Chemotherapy: A Randomized Controlled Study. Hindawi, vol. 2021, no. 2021, p. 1-10.

Jun, N. J., Mosaddik, A., Moon, J. Y., Jang, K. C., Lee, D. S., Ahn, K. S. and Cho, S. K. (2011). Cytotoxic activity of [beta]-Caryophyllene oxide isolated from jeju guava (Psidium cattleianum sabine) leaf. Records of Natural Products, vol. 5, no. 3, p. 242.

Kabala-Dzik, A., Rzepecka-Stojko. A., Kubina, R., Iriti, M., Wotyczka, R. D., Buszman, E. and Stojko, J. (2018). Flavonoids, bioactive components of propolis, exhibit cytotoxic activity and induce cell cycle arrest and apoptosis in human breast cancer cells MDA-MB-231 and MCF-7: A comparative study. Molecules, vol. 22, no. 9, p. 3-15.

Kalia, M. (2015). Biomarkers for personalized oncology: recent advances and future challenges. Metabolism, vol. 64, no. 3, p. 16-21.

Kamboj, A. and Saluja, A. K. (2011). Isolation of stigmasterol and ?-sitosterol from petroleum ether extract of aerial parts of Ageratum conyzoides (Asteraceae). Int. J. Pharm. Pharm. Sci, vol. 3, no. 1, p. 94-96.

Kaur, R., Singh, B. and Kaur, S. (2018). Pharmacognostic studies on leaves of Ageratum conyzoides Linn. Pharmacognosy and Phytochemistry, vol. 7, no. 3, p. 3181-3185.

Kementerian Kesehatan Republik Indonesia. (2011). Farmakope Herbal Indonesia : Suplemen II. hal. 5-8.

Kikuchi, H., Yuan, B., Hu, X. and Okazaki, M. (2019). Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents. American journal of cancer research, vol. 9, no. 8, p. 1517–1535.

Kotta, J. C., Lestari, A. B. S., Candrasari, D.S. dan Hariono, M. (2020). Medicinal Effect, in Silico Bioactivity Prediction, and Pharmaceutical Formulation of Ageratum conyzoides L.: A Review. Scientifica, vol. 1, no.1, p. 1-12 2020. https://doi.org/10.1155/2020/6420909

Lin, Z., Lin, Y., Shen, J., Jiang, M. and Hou, Y. (2020). Flavonoids in Ageratum conyzoides L. Exert potent antitumor effects on human cervical adenocarcinoma HeLa cells in vitro and in vivo. BioMed Research International, vol. 1, no. 1, p. 1-10 2020. https://doi.org/10.1155/2020/2696350

Lusiantika, L., Widowati, E.W. dan Adihimawati, M. (2019). Penentuan Aktivitas Antikanker Fraksi Etil Asetat Daun Bandotan (Ageratum conyzoides linn.) Terhadap Cell Line Kanker Kolon WiDr. ALKIMIA : Jurnal Ilmu Kimia dan Terapan, vol. 3, no. 2, p. 33–40.

McCauley, J., Zivanovic, A. and Skropeta, D. (2013). Bioassays for anticancer activities. Metabolomics Tools for Natural Product Discovery, vol. 1055, p. 191-205.

Melissa, M. dan Muchtaridi, M. (2017). Senyawa Aktif dan Manfaat Farmakologis Ageratum conyzoides. Farmaka, vol. 15, no. 1, p. 200-212.

Meiyanto, E., Hermawan, A. dan Anindyajati. (2012). Natural products for cancer-targeted therapy: Citrus flavonoids as potent chemopreventive agents. Asian Pacific Journal of Cancer Prevention, vol. 13, no. 2, p. 427–436.

Park, K.-R., D., Nam, H.-M., Yun, S.-G., Lee, H.-J., Jang, G., Sethi, G., Cho, S. K. and Ahn, K. S. (2011). ?-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Letters, vol. 312, no. 2, p. 178-188.

Pistritto, G., Trisciuoglio, D., Ceci, C., Gafuri, A. and D’Orazi, G. (2016). Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging, vol. 8, no. 4, p. 603-619.

Puro, K. N., Mazumder, M. U., Khazeo. P., Jyrwa, R., Jamir, N. and Sailo, L. (2018). Qualitative and quantitative analysis of phytochemicals of crude extracts of Ageratum conyzoides L. leaves. Perspective and Trends in the Development of Science Education and Research, vol. 178, p. 164-168.

Ratnasari, H., Rahma, A. dan Febriansah, R. (2019). The Effect of Ageratum conyzoides L on Hepatocellular Carcinoma Rats Induced by DMBA based on In Vivo-In Silico Study. Advances in Health Sciences Research, vol. 15, p. 1-6

Rhodes, L. V., Tate, C. R. and Hoang, V. T. (2015). Regulation of triple-negative breast cancer cell metastasis by the tumor suppressor liver kinase B1. Nature, vol. 406, no. 6797, p. 7-30.

Shah, S., Dhanani, T., Sharma, S., Singh, R., Kumar, R., Kumar, B., Srivastava, S., Ghosh, S., Kumar, R. and Juliet, S. (2020). Development and Validation of a Reversed Phase High Performance Liquid Chromatography-Photodiode Array Detection Method for Simultaneous Identification and Quantification of Coumarin, Precocene-I, b-Caryophyllene Oxide, a-Humulene, and b-Caryophyllene in Ageratum Conyzoides Extracts and Essential Oils from Plants. Journal of AOAC International, vol. 103, no. 3, p. 857–864

Shahwar, D., Ullah, S., Khan, M. A., Ahmad, N., Saees, A. and Ullah, S. (2015). Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells. Pakistan journal of pharmaceutical sciences, vol. 28, no. 3, p. 969-972.

Singh, S.B, Devi, W.R, Marina, A., Devi, I., Swapana, N. and Sing, C.B. (2013). Ethnobotany, Phytochemistry and Pharmacology Of Ageratum conyzoides Linn (Asteraceae). Journal of Medicinal Plants Research, vol. 7, no. 8, p. 371-385.

Silalahi M. (2018). Ageratum conyzoides L. (pemanfaatan sebagai obat dan bioaktivitasnya). Jurnal Dinamika Pendidikan, vol. 11, no. 3, p. 197–209.

Sukardiyono, S. dan Rosana, D. (2018). Utilization of Indonesian megabiodiversity for integrated science learning with nationalism values to develop concepts understanding and soft security among students of border areas. Journal of Science Education Research, vol. 2, no. 2, p. 56-65.

Suryati, L. R. dan Mukarlina. (2016). Kemampuan Ekstrak Daun Bandotan (Ageratum conyzoides L.) dalam Mempertahankan Kesegaran Buah Tomat (Solanum lycopersicum L. var. Permata). Protobiont, vol. 5, no. 1, p. 14–19.

Tambaru, E. (2017). Keragaman Jenis Tumbuhan Obat Adat di Sulawesi Selatan. Jurnal Ilmu Alam dan lingkungan, vol. 8, no. 15, p. 7- 13.

Walter, V., Fisher, C. and Deutsch, T. M. (2020). Estrogen, progesterone, and human epidermal growth factor receptor 2 discordance between primary and metastatic breast cancer. Breast Cancer Research and Treatment, vol. 183, no. 1, p. 137-144.

Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology - Head and Neck Surgery (United States).

Yadav, N., Ganie, S. A., Singh, B., Chhillar, A. K. and Yadav, S. S. (2019). Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L. Phytotherapy Research, vol. 33, no. 9, p. 2163-2178.

Yang, S. Y., Li, J. Y., Huang, G. J., Sridharan, B., Wang, J. S., Chang, K. M., Lee, M. J., Ji, Y., Li, S., Zhang, X., Li, Q., Lu, Q., Chen, W., Liu, Y., Sheng, J., Liang, H., Jiang, K., Li, M., Sha, S.,Wu, H., Huang, Y. and Xue, X. (2021). The Efficacy of Moxibustion for Breast Cancer Patient with Chemotherapy-Induced Myelosuppression during Adjuvant Chemotherapy: A Randomized Controlled Study. Hindawi, vol. 2021, no. 2021, p. 1-10.

Yin, S. Y., Wei, W. C., Jian, F. Y. and Yang, N. S. (2013). Therapeutic Application of Herbal Medicines for Cancer Patients. Evidence Based Complementary and Alternative Medicine,vol. 2013, p. 1-15.

Yip, C. H., Pathy, N. B. and Teo, S. H. (2014). A Review of Breast Cancer Research In Malaysia. Medical Journal Malaysia, 69, 8-22.2021. Effects of Water Extract of Cynanchum paniculatum (Bge.) Kitag. on Different Breast Cancer Cell Lines. Hindawi, vol. 2021, no. 2021, p. 1-13.

Yip, C. H., Pathy, N. B. and Teo, S. H. (2014). A Review of Breast Cancer Research In Malaysia. Medical Journal Malaysia, vol. 69, p. 8-22.




DOI: https://doi.org/10.31596/cjp.v6i1.153

Refbacks

  • There are currently no refbacks.


Journal Indexed by:

Google Scholar OneSearch Garuda Ristekdikti PKP Index Crossref

Copyright of Cendekia Journal of Pharmacy. ISSN: 2599-2163 (Print) dan 2599-2155 (Online).

Creative Commons License
This work is licensed under a Creative Commons Attribution 2.0 Generic License. Web
Analytics View My Stats